Yes, there are several factors to consider when dropping some money on an ereader.
Questions like: is a waterproof device important to you? Do you prefer to hold and operate your ereader in one hand? Do you need to borrow library books (particularly if you live outside the US), or would you prefer an ebook subscription service instead or buy directly from an ebook store? Do you read a lot of comics and graphic novels that are better on a color screen? Do you need to take notes in margins or require something for research and journaling?